Facioscapulohumeral muscular dystrophy (FSHD)
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common inherited muscle disorders of adulthood.1 It primarily causes progressive muscle weakness, often beginning in the face, shoulders, and upper arms, but it can also affect other muscle groups.2 FSHD is caused by aberrant expression of the DUX4 gene in skeletal muscle, leading to inflammation, cell death, and muscle atrophy.3,4
SV95C: a real-world measure of mobility for neuromuscular diseases
These resources provide more information on the Stride Velocity 95th Centile (SV95C) mobility test, a digital endpoint of ambulatory performance in patients’ normal daily environment.
Overview of SV95C and its use in clinical trials.
1. Tihaya MS, et al. Nature Rev Neurol. 2023;19(2):91–108; 2. Mul K, et al. Pract Neurol. 2016;16(3):201–207; 3. Mocciaro E, et al. Cells. 2021;10(12):3322; 4. Lim KRQ, et al. Int J Mol Sci. 2020;21(3):729.